The Developmental Genome Anatomy Project (DGAP) has been funded by the National Institutes of Health (NIH) through the National Institute of General Medical Sciences (NIGMS) since 1999.  DGAP uses naturally occurring human chromosome rearrangements found in association with major congenital anomalies to identify genes critical in human development. Various evolving genomics resources including an ordered BAC map of the human genome and the complete human DNA sequence are facilitating high throughput identification of these developmental genes.